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A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.
Entry Term(s)
Diaphorase (NADH Dehydrogenase)
NADH (Acceptor) Oxidoreductase
NADH Cytochrome c Oxidoreductase
NADH Cytochrome c Reductase
Registry Numbers
EC 1.6.99.3
CAS Type 1 Name
NADH:(acceptor) oxidoreductase
Previous Indexing
Cytochrome c (1973-1979)
Cytochrome Reductases (1973-1979)
NADH, NADPH Oxidoreductases (1973-1979)
Oxidoreductases (1966-1972)
Public MeSH Note
91; was see under CYTOCHROME REDUCTASES 1980-90
History Note
91(80); was see under CYTOCHROME REDUCTASES 1980-90
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.