MeSH Browser

MeSH Heading: Phosphodiesterase I
Tree Number(s): D08.811.277.352.640.430
Unique ID: D043264
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D043264
Scope Note: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
Entry Term(s): 5'-Exonuclease; 5'-Nucleotidephosphodiesterase; Alkaline Phosphodiesterase; Alkaline Phosphodiesterase I; Oligonucleate 5'-Nucleotidohydrolase; Orthophosphoric Diester Phosphohydrolase
Related Numbers: 9025-82-5
Previous Indexing: Phosphoric Diester Hydrolases (1978-2003)
Public MeSH Note: 2004; PHOSPHODIESTERASE I was indexed under PHOSPHORIC DIESTER HYDROLASES 1981-2003, under NUCLEOTIDES 1978-1980
History Note: 2004; use PHOSPHODIESTERASE I (NM) 1980-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0078260
Related Numbers: 9025-82-5
Scope Note: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
Terms: Phosphodiesterase I Preferred Term
Term UI T108263
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); 5'-Exonuclease
Term UI T108252
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); 5'-Nucleotidephosphodiesterase
Term UI T108254
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Alkaline Phosphodiesterase
Term UI T108257
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Alkaline Phosphodiesterase I
Term UI T108258
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Oligonucleate 5'-Nucleotidohydrolase
Term UI T531825
Date02/03/2003
LexicalTag NON
ThesaurusID NLM (2004); Orthophosphoric Diester Phosphohydrolase
Term UI T108260
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004)

Phosphodiesterase I MeSH Descriptor Data 2024