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Nuclear Receptor Subfamily 1, Group F, Member 1 MeSH Descriptor Data 2025
A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.
Entry Term(s)
Nuclear Receptor NR1F1
Nuclear Receptor ROR-alpha
Nuclear Receptor RZR-alpha
RAR-Related Orphan Receptor A
Retinoid-Related Orphan Receptor-alpha
Retinoid-Related Orphan Receptor-alpha1
Retinoid-Related Orphan Receptor-alpha2
Retinoid-Related Orphan Receptor-alpha3
Retinoid-Related Orphan Receptor-alpha4
Registry Numbers
0
Public MeSH Note
2010; RAR-RELATED ORPHAN RECEPTOR A (now NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1) was indexed under TRANS-ACTIVATORS and RECEPTORS, CYTOPLASMIC AND NUCLEAR 1996-2009
A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.