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CLOCK Proteins MeSH Descriptor Data 2022


MeSH Heading
CLOCK Proteins
Tree Number(s)
D08.811.913.050.134.415.500.049
D12.644.360.138.100
D12.776.260.103.562
D12.776.476.156.200
D12.776.930.125.562
Unique ID
D056926
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D056926
Scope Note
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Entry Term(s)
CLOCK Protein
Circadian Locomotor Output Cycles Kaput Proteins
Registry Number
EC 2.3.1.48
Public MeSH Note
2010; CLOCK PROTEIN (now CLOCK PROTEINS) was indexed under TRANSACTIVATORS 1997-2009
History Note
2010(1997)
Date Established
2010/01/01
Date of Entry
2009/07/06
Revision Date
2018/06/30
CLOCK Proteins Preferred
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