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Lysine Acetyltransferase 5 MeSH Descriptor Data 2022


MeSH Heading
Lysine Acetyltransferase 5
Tree Number(s)
D08.811.913.050.134.415.500.062
Unique ID
D000074443
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074443
Scope Note
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
Entry Term(s)
HIV-1-Tat Interactive Protein Tip60
HTATIP
KAT5 (TIP60) Protein
Registry Number
EC 2.3.1.48
Previous Indexing
Acetyltransferases (2002-2017)
Histone Acetyltransferases (2005-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/04/05
Lysine Acetyltransferase 5 Preferred
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