MeSH Browser

MeSH Heading: Transcription Factor HES-1
Tree Number(s): D12.776.260.103.844; D12.776.930.125.844
Unique ID: D000072056
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072056
Scope Note: A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
Entry Term(s): Hairy and Enhancer of Split 1 Protein; Hairy-Like Transcription Factor
Previous Indexing: Basic Helix-Loop-Helix Transcription Factors (1994-2016); Homeodomain Proteins (1994-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000616269
Scope Note: A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
Terms: Transcription Factor HES-1 Preferred Term
Term UI T000897939
Date03/30/2016
LexicalTag ACX
ThesaurusID NLM (2017); Hairy and Enhancer of Split 1 Protein
Term UI T000897940
Date03/30/2016
LexicalTag NON
ThesaurusID NLM (2017); Hairy-Like Transcription Factor
Term UI T000897942
Date03/30/2016
LexicalTag NON
ThesaurusID NLM (2017)

Transcription Factor HES-1 MeSH Descriptor Data 2024