MeSH Browser

MeSH Heading: Suppressor of Cytokine Signaling 1 Protein
Tree Number(s): D12.644.360.024.374.500; D12.776.157.057.249.500; D12.776.476.024.437.500
Unique ID: D000071222
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071222
Scope Note: A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
Entry Term(s): SOCS1 Protein; Suppressor of Cytokine Signaling Protein 1 -
Registry Numbers: 0
Previous Indexing: Carrier Proteins (1997-2016); Intracellular Signaling Peptides and Proteins (2004-2016); Repressor Proteins (2004-2016); Suppressor of Cytokine Signaling Proteins (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613665
Registry Numbers: 0
Scope Note: A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
Terms: Suppressor of Cytokine Signaling 1 Protein Preferred Term
Term UI T000893868
Date01/20/2016
LexicalTag NON
ThesaurusID NLM (2017); SOCS1 Protein
Term UI T000893865
Date01/20/2016
LexicalTag ACX
ThesaurusID NLM (2017); Suppressor of Cytokine Signaling Protein 1 -
Term UI T000893870
Date01/20/2016
LexicalTag NON
ThesaurusID NLM (2017)

Suppressor of Cytokine Signaling 1 Protein MeSH Descriptor Data 2024