- Concept UI
- M000613665
- Scope Note
- A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
- Terms
-
Suppressor of Cytokine Signaling 1 Protein
Preferred Term
Term UI
T000893868
Date01/20/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
SOCS1 Protein
Term UI
T000893865
Date01/20/2016
LexicalTag
ACX
ThesaurusID
NLM (2017)
-
Suppressor of Cytokine Signaling Protein 1 -
Term UI
T000893870
Date01/20/2016
LexicalTag
NON
ThesaurusID
NLM (2017)