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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha MeSH Descriptor Data 2022


MeSH Heading
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Tree Number(s)
D12.644.360.024.314.650
D12.776.157.057.080.650
D12.776.157.725.813.875
D12.776.476.024.394.650
D12.776.660.675.650
D12.776.664.962.813.875
D12.776.930.617.650
Unique ID
D000071248
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071248
Scope Note
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
Entry Term(s)
PGC-1-alpha Protein
PPARGC-1-alpha Protein
PPARGC1a Protein
Registry Number
0
Previous Indexing
Transcription Factors (2004-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/03/30
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Preferred
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