MeSH Browser

MeSH Heading: Src Homology 2 Domain-Containing, Transforming Protein 1
Tree Number(s): D12.644.360.024.330.500; D12.776.157.057.162.500; D12.776.476.024.424.500
Unique ID: D000071425
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071425
Scope Note: An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
Entry Term(s): SHC (Src Homology 2 Domain-Containing) Transforming Protein 1; SHC-Transforming Protein 1; SHC1 (Src Homology 2 Domain-Containing) Protein; SHC1 Protein; ShcA Protein; Src Homology 2 Domain-Containing-Transforming Protein C1
Public MeSH Note: 2017; see SHC SIGNALING ADAPTOR PROTEINS 2009-2016
History Note: 2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

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Src Homology 2 Domain-Containing, Transforming Protein 1 MeSH Descriptor Data 2024