MeSH Browser

MeSH Heading: Protein Kinase C-theta
Tree Number(s): D08.811.913.696.620.682.700.725.075; D12.776.476.563.725.075
Unique ID: D000074121
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074121
Scope Note: A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
Entry Term(s): PKC-theta; PRKCQ; Protein Kinase C theta; Protein Kinase C, theta
Previous Indexing: Isoenzymes (1992-2017); Protein Kinase C (1992-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625701
Scope Note: A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
Terms: Protein Kinase C-theta Preferred Term
Term UI T000914307
Date01/18/2017
LexicalTag NON
ThesaurusID NLM (2018); Protein Kinase C theta
Term UI T000914301
Date01/18/2017
LexicalTag NON
ThesaurusID NLM (2018); Protein Kinase C, theta
Term UI T000914303
Date01/18/2017
LexicalTag NON
ThesaurusID NLM (2018); PKC-theta
Term UI T000914304
Date01/18/2017
LexicalTag ABX
ThesaurusID NLM (2018); PRKCQ
Term UI T000914305
Date01/18/2017
LexicalTag ABB
ThesaurusID NLM (2018)

Protein Kinase C-theta MeSH Descriptor Data 2024