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Irinotecan MeSH Descriptor Data 2024


MeSH Heading
Irinotecan
Tree Number(s)
D03.132.151.425
Unique ID
D000077146
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077146
Scope Note
A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
Entry Term(s)
7-Ethyl-10-hydroxycamptothecin
CPT 11
CPT-11
Camptosar
Camptothecin-11
Irinotecan Hydrochloride
Irrinotecan
NK012 Compound
SN 38
SN 38 11
SN-38
SN-38-11
Pharm Action
Topoisomerase I Inhibitors
Registry Number
7673326042
Related Numbers
042LAQ1IIS
0H43101T0J
CAS Type 1 Name
(1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester
Public MeSH Note
2019; IRINOTECAN was indexed under CAMPTOTHECIN 1987-2018
History Note
2019 (1987)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/07/02
Irinotecan Preferred
SN 38 11 Narrower
SN 38 Narrower
NK012 Compound Narrower
CPT-11 Narrower
Camptosar Narrower
7-Ethyl-10-hydroxycamptothecin Narrower
Irinotecan Hydrochloride Narrower
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