MeSH Browser

MeSH Heading: Camptothecin
Tree Number(s): D03.132.151
Unique ID: D002166
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002166
Scope Note: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Entry Term(s): Camptothecine
Pharm Action: Antineoplastic Agents, Phytogenic
Topoisomerase I Inhibitors
Registry Number: XT3Z54Z28A
Related Numbers: 7689-03-4
CAS Type 1 Name: 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
Previous Indexing: Alkaloids (1966-1972); Antineoplastic Agents (1966-1972)
Public MeSH Note: 73
History Note: 73
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Camptothecin MeSH Descriptor Data 2024