MeSH Browser

MeSH Heading: Topotecan
Tree Number(s): D03.132.151.850
Unique ID: D019772
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019772
Scope Note: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Entry Term(s): 9-Dimethylaminomethyl-10-hydroxycamptothecin; Hycamtamine; Hycamtin; NSC-609699; Nogitecan Hydrochloride; SK&F-104864-A; SKF-104864-A; Topotecan Hydrochloride; Topotecan Monohydrochloride, (S)-Isomer
Pharm Action: Topoisomerase I Inhibitors
Registry Numbers: 7M7YKX2N15; 956S425ZCY; 0
Related Numbers: 119413-54-6; 123948-87-8; 956S425ZCY
Previous Indexing: Camptothecin/analogs & derivatives (1991-1997)
Public MeSH Note: 98; TOPOTECAN was indexed under CAMPTOTHECIN/analogs & derivatives 1991-97
History Note: 98; use TOPOTECAN (NM) 1991-97
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2017/01/17

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Topotecan MeSH Descriptor Data 2025