MeSH Browser

MeSH Heading: Decitabine
Tree Number(s): D02.145.150.500; D03.383.742.680.245.217.500; D13.570.685.245.217.500; D13.570.800.286.300.500
Unique ID: D000077209
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077209
Scope Note: An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.
Entry Term(s): 2'-Deoxy-5-azacytidine; 5-Aza-2'-deoxycytidine; 5-AzadC; 5-Azadeoxycytidine; 5-Deoxyazacytidine; 5AzadC; AzadC Compound; Dacogen; Decitabine Mesylate; NSC 127716; NSC-127716
Pharm Action: Antimetabolites, Antineoplastic
Enzyme Inhibitors
Related Numbers: 2353-33-5; 6U3LPL9PRN
See Also: Cytarabine
Public MeSH Note: 2019; DECITABINE was indexed under AZACITIDINE 1981-2018, and under DEOXYCITIDNE 1977-1980
History Note: 2019 (1977)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0062824
Related Numbers: 2353-33-5; 6U3LPL9PRN
Scope Note: An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.
Terms: Decitabine Preferred Term
Term UI T000937668
Date12/12/2017
LexicalTag NON
ThesaurusID; 5-Azadeoxycytidine
Term UI T000937671
Date12/12/2017
LexicalTag NON
ThesaurusID NLM (1977); AzadC Compound
Term UI T000937673
Date12/12/2017
LexicalTag ABX
ThesaurusID NLM (2015); 5-Aza-2'-deoxycytidine
Term UI T000937670
Date12/12/2017
LexicalTag NON
ThesaurusID NLM (2015); 5-AzadC
Term UI T000938328
Date12/28/2017
LexicalTag ABB
ThesaurusID NLM (2019); 2'-Deoxy-5-azacytidine
Term UI T000937669
Date12/12/2017
LexicalTag NON
ThesaurusID NLM (1977); 5AzadC
Term UI T000938327
Date12/28/2017
LexicalTag ABB
ThesaurusID NLM (2019)

Decitabine MeSH Descriptor Data 2024