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RNA, Guide, CRISPR-Cas Systems MeSH Descriptor Data 2024


MeSH Heading
RNA, Guide, CRISPR-Cas Systems
Tree Number(s)
D13.444.735.790.552.563
Unique ID
D000094704
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000094704
Annotation
do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA)
Scope Note
A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.
Entry Term(s)
CRISPR Guide RNA
CRISPR-Cas Systems sgRNA (Single Guide RNA)
Guide RNA (CRISPR-Cas Systems)
Guide RNA, CRISPR-Cas Systems
RNA, CRISPR Guide
RNA, Guide (CRISPR-Cas Systems)
RNA, Single Guide
RNA, Single-Guide
Single Guide RNA
Single-Guide RNA
Transactivating crRNA
crRNA
crRNA, Transactivating
sgRNA (CRISPR-Cas Systems)
sgRNA (Single-Guide RNA)
tracrRNA
Previous Indexing
CRISPR-Cas Systems (2014-2022)
RNA, Guide, CRISPR-Cas Systems (2008-2022)
See Also
CRISPR-Cas Systems
Public MeSH Note
2023
History Note
2023
Date Established
2023/01/01
Date of Entry
2022/07/11
Revision Date
2022/07/11
RNA, Guide, CRISPR-Cas Systems Preferred
RNA, CRISPR Guide Narrower
RNA, Single Guide Narrower
crRNA, Transactivating Narrower
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