MeSH Browser

MeSH Heading: MicroRNAs
Tree Number(s): D13.150.650.319; D13.444.735.150.319; D13.444.735.790.552.500
Unique ID: D035683
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D035683
Scope Note: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Entry Term(s): Micro RNA; MicroRNA; Primary MicroRNA; Primary miRNA; RNA, Small Temporal; Small Temporal RNA; miRNA; miRNAs; pre-miRNA; pri-miRNA; stRNA
Registry Number: 0
Previous Indexing: RNA, Antisense (2001-2002); RNA, Untranslated (2001-2002)
See Also: RNA, Small Interfering
Public MeSH Note: 2003; MICRORNAS was indexed under RNA, UNTRANSLATED and RNA, ANTISENSE 2001-2002
History Note: 2003; use MICRORNAS (NM) 2001-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0407989
Registry Number: 0
Scope Note: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Terms: MicroRNAs Preferred Term
Term UI T474060
Date12/17/2001
LexicalTag ACX
ThesaurusID NLM (2003); MicroRNA
Term UI T474063
Date12/17/2001
LexicalTag ACX
ThesaurusID NLM (2003); miRNAs
Term UI T474061
Date12/17/2001
LexicalTag ACX
ThesaurusID NLM (2003); Micro RNA
Term UI T474062
Date12/17/2001
LexicalTag ACX
ThesaurusID NLM (2003); miRNA
Term UI T474064
Date12/17/2001
LexicalTag ACX
ThesaurusID NLM (2003)

MicroRNAs MeSH Descriptor Data 2024