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MicroRNAs MeSH Descriptor Data 2022


MeSH Heading
MicroRNAs
Tree Number(s)
D13.150.650.319
D13.444.735.150.319
D13.444.735.790.552.500
Unique ID
D035683
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D035683
Scope Note
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Entry Term(s)
Micro RNA
MicroRNA
Primary MicroRNA
Primary miRNA
RNA, Small Temporal
Small Temporal RNA
miRNA
miRNAs
pre-miRNA
pri-miRNA
stRNA
Registry Number
0
Previous Indexing
RNA, Antisense (2001-2002)
RNA, Untranslated (2001-2002)
See Also
RNA, Small Interfering
Public MeSH Note
2003; MICRORNAS was indexed under RNA, UNTRANSLATED and RNA, ANTISENSE 2001-2002
History Note
2003; use MICRORNAS (NM) 2001-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2013/07/09
MicroRNAs Preferred
Primary MicroRNA Narrower
RNA, Small Temporal Narrower
pre-miRNA Narrower
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