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RNA, Small Interfering MeSH Descriptor Data 2022


MeSH Heading
RNA, Small Interfering
Tree Number(s)
D13.150.650.700
D13.444.735.150.700
D13.444.735.790.552.875
Unique ID
D034741
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D034741
Annotation
Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
Scope Note
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Entry Term(s)
Piwi-Interacting RNA
RNA, Piwi-Interacting
RNA, Scan
Repeat-Associated siRNA
Scan RNA
Short Hairpin RNA
Short Interfering RNA
Small Hairpin RNA
Small Interfering RNA
Small Scan RNA
Trans-Acting siRNA
piRNA
scnRNA
shRNA
siRNA
siRNA, Repeat-Associated
siRNA, Trans-Acting
tasiRNA
Registry Number
0
See Also
MicroRNAs
RNA Interference
RNA-Induced Silencing Complex
Public MeSH Note
2003; RNA, SMALL INTERFERING was indexed under RNA, UNTRANSLATED 2001-2002
History Note
2003; use RNA, SMALL INTERFERING (NM) 2001-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2010/06/25
RNA, Small Interfering Preferred
Piwi-Interacting RNA Narrower
Short Hairpin RNA Narrower
Repeat-Associated siRNA Related
Scan RNA Narrower
Trans-Acting siRNA Narrower
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