MeSH Browser

MeSH Heading: Exostosin 1
Tree Number(s): D08.811.913.400.001.250; D08.811.913.400.100.250.250
Unique ID: D000099058
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099058
Scope Note: A bifunctional glycosyltransferase involved in transferring GLUCURONIC ACID and N-ACETYLGLUCOSAMINE in the elongation of HEPARAN SULFATE chains. Mutations in the gene EXT1, coding for this protein (as well as mutations in other genes), are responsible for defects in heparan sulfate synthesis resulting in HEREDITARY MULTIPLE EXOSTOSES. Exostosin-1, along with EXOSTOSIN-2, is a component of heparan sulfate polymerase.
Entry Term(s): EXT1 Heparan Sulfate Copolymerase; Exostosin-1; Heparan Sulfate Copolymerase EXT1; Multiple Exostoses Protein 1
Registry Numbers: EC 2.4.1.224; EC 2.4.1.225
Public MeSH Note: 2025; EXOSTOSIN-1 was indexed under N-ACETYLGLUCOSAMINYLTRANSFERASES1997-2024
History Note: 2025 (1997)
Date Established: 2025/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/07/17

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0274532
Registry Numbers: EC 2.4.1.224; EC 2.4.1.225
Scope Note: A bifunctional glycosyltransferase involved in transferring GLUCURONIC ACID and N-ACETYLGLUCOSAMINE in the elongation of HEPARAN SULFATE chains. Mutations in the gene EXT1, coding for this protein (as well as mutations in other genes), are responsible for defects in heparan sulfate synthesis resulting in HEREDITARY MULTIPLE EXOSTOSES. Exostosin-1, along with EXOSTOSIN-2, is a component of heparan sulfate polymerase.
Terms: Exostosin 1 Preferred Term
Term UI T001144437
Date05/30/2024
LexicalTag NON
ThesaurusID NLM (2025); Exostosin-1
Term UI T001144369
Date05/17/2024
LexicalTag NON
ThesaurusID NLM (2000); EXT1 Heparan Sulfate Copolymerase
Term UI T001144376
Date05/20/2024
LexicalTag NON
ThesaurusID NLM (2000); Heparan Sulfate Copolymerase EXT1
Term UI T001144377
Date05/20/2024
LexicalTag NON
ThesaurusID NLM (2000); Multiple Exostoses Protein 1
Term UI T001144378
Date05/20/2024
LexicalTag NON
ThesaurusID NLM (2006)

Exostosin 1 MeSH Descriptor Data 2025