MeSH Browser

MeSH Heading: Exostosin 2
Tree Number(s): D08.811.913.400.001.300; D08.811.913.400.100.250.300
Unique ID: D000099065
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099065
Scope Note: A bifunctional glycosyltransferase involved in transferring GLUCURONIC ACID and N-ACETYLGLUCOSAMINE in the elongation of HEPARAN SULFATE chains. Mutations in the gene EXT2, coding for this protein (as well as mutations in other genes), are responsible for defects in heparan sulfate synthesis resulting in chromosome 11-linked HEREDITARY MULTIPLE EXOSTOSES. Exostosin 2, along with EXOSTOSIN 1, is a component of heparan sulfate polymerase.
Entry Term(s): Exostosin-2; Multiple Exostoses Protein 2
Registry Numbers: EC 2.4.1.224; EC 2.4.1.225
Public MeSH Note: 2025; EXOSTOSIN-2 was indexed under N-ACETYLGLUCOSAMINYLTRANSFERASES 1996-2024
History Note: 2025 (1996)
Date Established: 2025/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/07/17

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0265859
Registry Numbers: EC 2.4.1.224; EC 2.4.1.225
Scope Note: A bifunctional glycosyltransferase involved in transferring GLUCURONIC ACID and N-ACETYLGLUCOSAMINE in the elongation of HEPARAN SULFATE chains. Mutations in the gene EXT2, coding for this protein (as well as mutations in other genes), are responsible for defects in heparan sulfate synthesis resulting in chromosome 11-linked HEREDITARY MULTIPLE EXOSTOSES. Exostosin 2, along with EXOSTOSIN 1, is a component of heparan sulfate polymerase.
Terms: Exostosin 2 Preferred Term
Term UI T001144439
Date05/31/2024
LexicalTag NON
ThesaurusID NLM (2025); Exostosin-2
Term UI T001144440
Date05/31/2024
LexicalTag NON
ThesaurusID NLM (2025); Multiple Exostoses Protein 2
Term UI T001144441
Date05/31/2024
LexicalTag NON
ThesaurusID NLM (2025)

Exostosin 2 MeSH Descriptor Data 2025