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Amiloride MeSH Descriptor Data 2024


MeSH Heading
Amiloride
Tree Number(s)
D03.383.679.149
Unique ID
D000584
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000584
Scope Note
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Entry Term(s)
Amidal
Amiduret Trom
Amiloberag
Amiloride Hydrochloride
Amiloride Hydrochloride, Anhydrous
Kaluril
Midamor
Midoride
Modamide
Pharm Action
Diuretics
Acid Sensing Ion Channel Blockers
Epithelial Sodium Channel Blockers
Related Numbers
17440-83-4
2016-88-8
2609-46-3
FZJ37245UC
CAS Type 1 Name
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
NLM Classification #
QV 160
Previous Indexing
Diuretics (1966-1971)
Pyrazines (1966-1971)
Public MeSH Note
86; was see under PYRAZINES 1975-85
History Note
86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
Date Established
1986/01/01
Date of Entry
1999/01/01
Revision Date
2017/05/24
Amiloride Preferred
Midamor Narrower
Amiloride Hydrochloride Narrower
Amiloride Hydrochloride, Anhydrous Narrower
Amidal Narrower
Amiduret Trom Narrower
Amiloberag Narrower
Kaluril Narrower
Midoride Narrower
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