MeSH Browser

MeSH Heading: Cardiac Glycosides
Tree Number(s): D04.210.500.155.580; D09.408.180
Unique ID: D002301
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002301
Scope Note: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Entry Term(s): Cardiac Glycoside; Cardiotonic Steroid; Cardiotonic Steroids
Pharm Action: Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
NLM Classification #: QV 153
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0003451
Scope Note: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Terms: Cardiac Glycosides Preferred Term
Term UI T006613
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Cardiotonic Steroid
Term UI T001005742
Date01/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Cardiotonic Steroids
Term UI T006614
Date04/22/1976
LexicalTag NON
ThesaurusID UNK (19XX); Cardiac Glycoside
Term UI T001005743
Date01/17/2020
LexicalTag NON
ThesaurusID NLM (2021)

Cardiac Glycosides MeSH Descriptor Data 2024