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Epidermal Growth Factor MeSH Descriptor Data 2022


MeSH Heading
Epidermal Growth Factor
Tree Number(s)
D06.472.317.350
D12.644.276.382.500
D12.776.467.382.500
D23.529.382.500
Unique ID
D004815
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004815
Scope Note
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Entry Term(s)
EGF
Epidermal Growth Factor-Urogastrone
Human Urinary Gastric Inhibitor
Urogastrone
beta-Urogastrone
Registry Number
62229-50-9
CAS Type 1 Name
Epidermal growth factor
NLM Classification #
WK 170
Previous Indexing
Gastrointestinal Hormones (1966-1974)
Growth Substances (1966-1976)
Peptides (1966-1976)
See Also
Anti-Ulcer Agents
ErbB Receptors
Gastrointestinal Agents
Public MeSH Note
2000; see EPIDERMAL GROWTH FACTOR-UROGASTRONE 1982-1999, see PEPTIDES 1977-1981; for UROGASTRONE see GASTROINTESTINAL HORMONES 1963-1981
History Note
2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981
Date Established
1982/01/01
Date of Entry
1976/04/16
Revision Date
2018/07/02
Epidermal Growth Factor Preferred
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