A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Entry Term(s)
Astrocytoma, Grade IV
Giant Cell Glioblastoma
Glioblastoma Multiforme
Public MeSH Note
94; was GLIOBLASTOMA MULTIFORME 1963-93; GLIOBLASTOMA was see ASTROCYTOMA 1993
Online Note
use GLIOBLASTOMA to search GLIOBLASTOMA MULTIFORME 1966-93; search GLIOBLASTOMA under GLIOMA 1980-93
History Note
94; was GLIOBLASTOMA MULTIFORME 1963-93; GLIOBLASTOMA was see ASTROCYTOMA 1993
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
