MeSH Browser

MeSH Heading: Mechlorethamine
Tree Number(s): D02.455.526.728.650.529
Unique ID: D008466
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008466
Scope Note: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Entry Term(s): Bis(2-chloroethyl)methylamine; Caryolysine; Chlorethazine; Chlormethine; Cloramin; Embichin; Mechlorethamine Hydrochloride; Mechlorethamine Hydrochloride N-Oxide; Mechlorethamine N-Oxide; Mechlorethamine Oxide; Methylchlorethamine; Mitomen; Mustargen; Mustine; NSC-10107; NSC-762; Nitrogen Mustard; Nitrogen Mustard N-Oxide; Nitrogranulogen; Nitromin
Pharm Action: Alkylating Agents
Chemical Warfare Agents
Irritants
Antineoplastic Agents, Alkylating
Related Numbers: 126-85-2; 302-70-5; 51-75-2; 55-86-7; L0MR697HHI
CAS Type 1 Name: Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
NLM Classification #: QV 269
Public MeSH Note: MECHLORETHAMINE OXIDE was heading 1963-79; NITROGEN MUSTARD N-OXIDE was indexed under NITROGEN MUSTARD COMPOUNDS 1984-91
Online Note: use MECHLORETHAMINE to search MECHLORETHAMINE OXIDE 1966-79; use MECHLORETHAMINE (NM) to search NITROGEN MUSTARD N-OXIDE (NM) 1984-91
History Note: MECHLORETHAMINE OXIDE was heading 1963-79; NITROGEN MUSTARD N-OXIDE was NITROGEN MUSTARD N-OXIDE (NM) 1984-91
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Halogenated [D02.455.526]
    - Mustard Compounds [D02.455.526.728]
      - Nitrogen Mustard Compounds [D02.455.526.728.650]
        
        Aniline Mustard [D02.455.526.728.650.050]
        
        Bendamustine Hydrochloride [D02.455.526.728.650.103]
        
        Chlorambucil [D02.455.526.728.650.156]
        
        Estramustine [D02.455.526.728.650.275]
        
        Mannomustine [D02.455.526.728.650.463]
        
        Mechlorethamine [D02.455.526.728.650.529]
        
        Melphalan [D02.455.526.728.650.594]
        
        Phosphoramide Mustards [D02.455.526.728.650.730]
        
        Propylbenzilylcholine Mustard [D02.455.526.728.650.740]
        
        Quinacrine Mustard [D02.455.526.728.650.760]
        
        Uracil Mustard [D02.455.526.728.650.913]

Mechlorethamine Preferred

Concept UI: M0013168
Related Numbers: 126-85-2; 302-70-5; 51-75-2; 55-86-7; L0MR697HHI
Scope Note: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Terms: Mechlorethamine Preferred Term
Term UI T025155
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Chlorethazine
Term UI T025151
Date04/09/1980
LexicalTag NON
ThesaurusID UNK (19XX); Chlormethine
Term UI T025152
Date04/09/1980
LexicalTag NON
ThesaurusID; Mustine
Term UI T025157
Date04/09/1980
LexicalTag NON
ThesaurusID BAN (19XX); Methylchlorethamine
Term UI T025156
Date03/31/1982
LexicalTag NON
ThesaurusID UNK (19XX); Nitrogen Mustard
Term UI T025159
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX); Bis(2-chloroethyl)methylamine
Term UI T025160
Date03/20/1991
LexicalTag NON
ThesaurusID NLM (1992)

Mechlorethamine Oxide Narrower

Nitrogranulogen Narrower

Nitromin Narrower

Embichin Narrower

Mechlorethamine Hydrochloride Narrower

Mustargen Narrower

NSC-762 Narrower

Mechlorethamine N-Oxide Narrower

Mechlorethamine Hydrochloride N-Oxide Narrower

Cloramin Narrower

NSC-10107 Narrower

Caryolysine Narrower

Mitomen Narrower

Mechlorethamine MeSH Descriptor Data 2024