MeSH Browser

MeSH Heading: Melphalan
Tree Number(s): D02.455.526.728.650.594; D12.125.072.050.685.500
Unique ID: D008558
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008558
Scope Note: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Entry Term(s): 4-(Bis(2-chloroethyl)amino)phenylalanine; Alkeran; L-PAM; Medphalan; Merphalan; Phenylalanine Mustard; Sarcolysine; Sarkolysin
Pharm Action: Antineoplastic Agents, Alkylating
Myeloablative Agonists
Related Numbers: 148-82-3
CAS Type 1 Name: L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
Public MeSH Note: PEPTICHEMIO was see under NITROGEN MUSTARD COMPOUNDS 1975-80
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0013330
Related Numbers: 148-82-3
Scope Note: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Terms: Melphalan Preferred Term
Term UI T025464
Date01/01/1999
LexicalTag NON
ThesaurusID; 4-(Bis(2-chloroethyl)amino)phenylalanine
Term UI T025462
Date07/28/1981
LexicalTag NON
ThesaurusID UNK (19XX); L-PAM
Term UI T025463
Date02/04/1982
LexicalTag ABB
ThesaurusID; Phenylalanine Mustard
Term UI T025465
Date12/10/1974
LexicalTag NON
ThesaurusID

Melphalan MeSH Descriptor Data 2024