MeSH Browser

MeSH Heading: Methysergide
Tree Number(s): D03.132.327.287.689; D03.633.400.439.689
Unique ID: D008784
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008784
Scope Note: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Entry Term(s): Deseril; Desril; Dimethylergometrin; Désernil-Sandoz; Methylmethylergonovine; Methysergide Dimaleate; Methysergide Maleate; Sansert; UML-491
Pharm Action: Serotonin Antagonists
Vasoconstrictor Agents
Related Numbers: 129-49-7; 2U7H1466GH; 361-37-5
CAS Type 1 Name: Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethyl-, (8beta(S))-
Public MeSH Note: 65; METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74
Online Note: use METHYSERGIDE/analogs & derivatives to search METHYSERGIDE DERIVATIVES 1975-77; use ERGOLINES 1969-74
History Note: 65(63); METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0013673
Related Numbers: 129-49-7; 2U7H1466GH; 361-37-5
Scope Note: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Terms: Methysergide Preferred Term
Term UI T026199
Date01/01/1999
LexicalTag NON
ThesaurusID; Dimethylergometrin
Term UI T026197
Date04/24/1976
LexicalTag NON
ThesaurusID UNK (19XX); Methylmethylergonovine
Term UI T026198
Date12/24/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Methysergide MeSH Descriptor Data 2024