MeSH Browser

MeSH Heading: RNA Caps
Tree Number(s): D03.633.100.759.646.454.700; D13.444.735.544.500; D13.695.667.454.700; D13.695.827.426.700
Unique ID: D012315
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012315
Annotation: IM; /‌drug eff /‌ultrastruct permitted
Scope Note: Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Entry Term(s): 5' Capped RNA; 5' mRNA Cap Structure; RNA Cap
NLM Classification #: QU 58.7
Previous Indexing: Guanine Nucleotides (1966-1971); Guanosine Triphosphate (1972-1974)/analogs & derivatives (1975-1979); Oligoribonucleotides (1976-1979); Ribonucleotides (1971-1975); RNA, Messenger (1966-1979)
Public MeSH Note: 80
History Note: 80
Entry Combination: analogs & derivatives:RNA Cap Analogs
Date Established: 1980/01/01
Date of Entry: 1979/05/23
Revision Date: 2021/06/30

Entry Combination: analogs & derivatives:RNA Cap Analogs
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0019141
Scope Note: Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Terms: RNA Caps Preferred Term
Term UI T036556
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1980); RNA Cap
Term UI T001089430
Date10/06/2020
LexicalTag NON
ThesaurusID NLM (2022); 5' mRNA Cap Structure
Term UI T487920
Date03/28/2002
LexicalTag ACX
ThesaurusID NLM (2003); 5' Capped RNA
Term UI T487921
Date03/28/2002
LexicalTag ACX
ThesaurusID NLM (2003)

RNA Caps MeSH Descriptor Data 2024