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Shwartzman Phenomenon MeSH Descriptor Data 2022


MeSH Heading
Shwartzman Phenomenon
Tree Number(s)
C14.907.454.810
C14.907.940.890
C15.378.463.515.810
Unique ID
D012790
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D012790
Scope Note
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
Entry Term(s)
Schwartzman Phenomenon
Schwartzman Reaction
Shwartzman Reaction
NLM Classification #
WH 312
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2010/06/25
Shwartzman Phenomenon Preferred
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