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Shwartzman Phenomenon MeSH Descriptor Data 2024

MeSH Heading
Shwartzman Phenomenon
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
Entry Term(s)
Schwartzman Phenomenon
Schwartzman Reaction
Shwartzman Reaction
NLM Classification #
WH 312
Date Established
Date of Entry
Revision Date
Shwartzman Phenomenon Preferred
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