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Farnesyl-Diphosphate Farnesyltransferase MeSH Descriptor Data 2022


MeSH Heading
Farnesyl-Diphosphate Farnesyltransferase
Tree Number(s)
D08.811.913.225.431
Unique ID
D013186
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013186
Scope Note
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Entry Term(s)
FPP-FPP Farnesyl Transferase
Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
Presqualene-Diphosphate Synthase
Squalene Synthase
Squalene Synthetase
Registry Number
EC 2.5.1.21
Previous Indexing
Farnesol (1972-1974)
Ligases (1972-1974)
Pyrophosphoric Acids (1972-1974)
Squalene (1972-1974)
Public MeSH Note
2006; see OXIDOREDUCTASES 1975-1990; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE was indexed under OXIDOREDUCTASES & SQUALENE SYNTHETASE 1998-2001
History Note
2006(1975)
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2009/07/13
Farnesyl-Diphosphate Farnesyltransferase Preferred
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