MeSH Browser

MeSH Heading: Farnesyl-Diphosphate Farnesyltransferase
Tree Number(s): D08.811.913.225.431
Unique ID: D013186
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013186
Scope Note: The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Entry Term(s): FPP-FPP Farnesyl Transferase; Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase; Presqualene-Diphosphate Synthase; Squalene Synthase; Squalene Synthetase
Registry Number: EC 2.5.1.21
Previous Indexing: Farnesol (1972-1974); Ligases (1972-1974); Pyrophosphoric Acids (1972-1974); Squalene (1972-1974)
Public MeSH Note: 2006; see OXIDOREDUCTASES 1975-1990; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE was indexed under OXIDOREDUCTASES & SQUALENE SYNTHETASE 1998-2001
History Note: 2006(1975)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0020401
Registry Number: EC 2.5.1.21
Scope Note: The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Terms: Farnesyl-Diphosphate Farnesyltransferase Preferred Term
Term UI T327174
LexicalTag NON
ThesaurusID NLM (2006); FPP-FPP Farnesyl Transferase
Term UI T327171
LexicalTag ABX
ThesaurusID NLM (2006); Squalene Synthase
Term UI T528461
Date12/16/2002
LexicalTag NON
ThesaurusID NLM (2004); Squalene Synthetase
Term UI T038733
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
Term UI T327172
LexicalTag NON
ThesaurusID NLM (2006); Presqualene-Diphosphate Synthase
Term UI T327173
LexicalTag NON
ThesaurusID NLM (2006)

Farnesyl-Diphosphate Farnesyltransferase MeSH Descriptor Data 2024