MeSH Browser

MeSH Heading: Thyrotropin-Releasing Hormone
Tree Number(s): D06.472.699.327.740.880; D12.644.400.400.740.880; D12.644.456.837; D12.644.548.365.740.880; D12.776.631.650.405.740.880; D12.776.631.650.810
Unique ID: D013973
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013973
Scope Note: A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.
Entry Version: TRH
Entry Term(s): Abbott-38579; Antepan; Proterelin Tartrate; Proterelin Tartrate Hydrate; Protirelin; Protirelin Tartrate (1:1); Relefact TRH; Stimu-TSH; TRH Ferring; TRH Prem; Thypinone; Thyroliberin; Thyroliberin TRH Merck; Thyrotropin-Releasing Factor; Thyrotropin-Releasing Hormone Tartrate
Pharm Action: Hormones
Registry Numbers: 5Y5F15120W; 0; SYW8T997EQ; 1N3H4TJE79
Related Numbers: 1N3H4TJE79; 24305-27-9; SYW8T997EQ
CAS Type 1 Name: pyroGlu-His-Pro-NH2 (or 5-oxo-L-prolyl-L-histidyl-L-prolinamide)
NLM Classification #: WK 515
Previous Indexing: Hypothalamo-Hypophyseal System/physiology (1966-1967); Thyrotropin/biosynthesis (1966-1967); Thyrotropin/metabolism (1966-1967)
See Also: Receptors, Thyrotropin-Releasing Hormone
Public MeSH Note: 2006; see PROTIRELIN 1992-2005, see THYROTROPIN-RELEASING HORMONE 1991, see THYROTROPIN RELEASING HORMONE 1974-1990, see THYROTROPIN RELEASING FACTOR 1968-1973
History Note: 2006(1968)
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pituitary Hormone-Releasing Hormones [D06.472.699.327.740]
        
        Corticotropin-Releasing Hormone [D06.472.699.327.740.140]
        
        Gonadotropin-Releasing Hormone [D06.472.699.327.740.320]
        
        Growth Hormone-Releasing Hormone [D06.472.699.327.740.860]
        
        Thyrotropin-Releasing Hormone [D06.472.699.327.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pituitary Hormone-Releasing Hormones [D12.644.400.400.740]
        
        Corticotropin-Releasing Hormone [D12.644.400.400.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.400.400.740.320]
        
        Growth Hormone-Releasing Hormone [D12.644.400.400.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.400.400.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Oligopeptides [D12.644.456]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pituitary Hormone-Releasing Hormones [D12.644.548.365.740]
        
        Corticotropin-Releasing Hormone [D12.644.548.365.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.548.365.740.320]
        
        Growth Hormone-Releasing Hormone [D12.644.548.365.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.548.365.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
        
        Corticotropin-Releasing Hormone [D12.776.631.650.405.740.140]
        
        Gonadotropin-Releasing Hormone [D12.776.631.650.405.740.320]
        
        Growth Hormone-Releasing Hormone [D12.776.631.650.405.740.860]
        
        Thyrotropin-Releasing Hormone [D12.776.631.650.405.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]

Thyrotropin-Releasing Hormone Preferred

Concept UI: M0021497
Registry Numbers: 5Y5F15120W
Related Numbers: 1N3H4TJE79; 24305-27-9; SYW8T997EQ
Scope Note: A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.
Terms: Thyrotropin-Releasing Hormone Preferred Term
Term UI T040975
Date01/16/1991
LexicalTag NON
ThesaurusID; Protirelin
Term UI T040973
Date01/01/1999
LexicalTag NON
ThesaurusID; Thyrotropin-Releasing Factor
Term UI T665155
Date01/26/2006
LexicalTag NON
ThesaurusID

Relefact TRH Narrower

Thypinone Narrower

Protirelin Tartrate (1:1) Narrower

Abbott-38579 Narrower

Thyroliberin Narrower

Antepan Narrower

Stimu-TSH Narrower

TRH Prem Narrower

Proterelin Tartrate Hydrate Narrower

Thyrotropin-Releasing Hormone MeSH Descriptor Data 2025