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Trimethoprim
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Trimethoprim
Tree Number(s)
D03.383.742.906
Unique ID
D014295
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D014295
Annotation
consider
TRIMETHOPRIM RESISTANCE
for nonsusceptibility of bacteria
Scope Note
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to
PYRIMETHAMINE
. It is potentiated by
SULFONAMIDES
and the
TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION
is the form most often used. It is sometimes used alone as an antimalarial.
TRIMETHOPRIM RESISTANCE
has been reported.
Entry Term(s)
Proloprim
Trimpex
Pharm Action
Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
Registry Numbers
AN164J8Y0X
0
Related Numbers
738-70-5
CAS Type 1 Name
2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
NLM Classification #
QV 256
Previous Indexing
Anti-Infective Agents (1966-1971)
Folic Acid Antagonists (1966-1971)
Pyrimidines (1966-1971)
See Also
Trimethoprim Resistance
Public MeSH Note
1974
History Note
1974 (1972)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2018/05/21
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analogs & derivatives (AA)
analysis (AN)
antagonists & inhibitors (AI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Bosentan [D03.383.742.060]
Buspirone [D03.383.742.120]
Dasatinib [D03.383.742.148]
Dipyridamole [D03.383.742.175]
Epirizole [D03.383.742.200]
Hexetidine [D03.383.742.279]
Imatinib Mesylate [D03.383.742.349]
Minoxidil [D03.383.742.418]
Mopidamol [D03.383.742.430]
Morantel [D03.383.742.440]
Nicarbazin [D03.383.742.470]
Oxypurinol [D03.383.742.550]
Paliperidone Palmitate [D03.383.742.592]
Pyrantel [D03.383.742.634]
Pyrimethamine [D03.383.742.675]
Pyrimidine Nucleosides [D03.383.742.680]
Pyrimidine Nucleotides [D03.383.742.686]
Pyrimidinones [D03.383.742.698]
Pyrithiamine [D03.383.742.715]
Rilpivirine [D03.383.742.755]
Rosuvastatin Calcium [D03.383.742.775]
Thiamine [D03.383.742.795]
Trapidil [D03.383.742.875]
Trimethoprim [D03.383.742.906]
Trimethoprim, Sulfamethoxazole Drug Combination [D03.383.742.906.500]
Expand All
Collapse All
Trimethoprim
Preferred
Concept UI
M0021991
Registry Numbers
AN164J8Y0X
Related Numbers
738-70-5
Scope Note
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to
PYRIMETHAMINE
. It is potentiated by
SULFONAMIDES
and the
TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION
is the form most often used. It is sometimes used alone as an antimalarial.
TRIMETHOPRIM RESISTANCE
has been reported.
Terms
Trimethoprim
Preferred Term
Term UI
T041851
Date
01/01/1999
LexicalTag
NON
ThesaurusID
Trimpex
Narrower
Concept UI
M0373256
Registry Numbers
0
Terms
Trimpex
Preferred Term
Term UI
T041852
Date
11/18/1986
LexicalTag
TRD
ThesaurusID
UNK (19XX)
Proloprim
Narrower
Concept UI
M0373257
Registry Numbers
0
Terms
Proloprim
Preferred Term
Term UI
T041850
Date
11/18/1986
LexicalTag
TRD
ThesaurusID
UNK (19XX)
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