MeSH Browser

MeSH Heading: Complement C1q
Tree Number(s): D12.776.124.486.274.050.270
Unique ID: D015922
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015922
Scope Note: A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Entry Term(s): C1q Complement; Complement 1q; Complement Component 1q
Pharm Action: Immunologic Factors
CAS Type 1 Name: Complement C1q
Previous Indexing: Complement 1 (1980-1989); Complement Activating Enzymes (1979-1989)
Public MeSH Note: 2006; see COMPLEMENT 1Q 1990-2005
History Note: 2006 (1990)
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024366
Scope Note: A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Terms: Complement C1q Preferred Term
Term UI T622146
Date12/06/2004
LexicalTag NON
ThesaurusID NLM (2006); C1q Complement
Term UI T631371
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 1q
Term UI T047237
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Complement Component 1q
Term UI T622147
Date12/06/2004
LexicalTag NON
ThesaurusID NLM (2006)

Complement C1q MeSH Descriptor Data 2024