- Concept UI
- M0024366
- Registry Numbers
- 80295-33-6
- Scope Note
- A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
- Terms
-
Complement C1q
Preferred Term
Term UI
T622146
Date12/06/2004
LexicalTag
NON
ThesaurusID
NLM (2006)
-
C1q Complement
Term UI
T631371
Date02/23/2005
LexicalTag
NON
ThesaurusID
NLM (2006)
-
Complement 1q
Term UI
T047237
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Complement Component 1q
Term UI
T622147
Date12/06/2004
LexicalTag
NON
ThesaurusID
NLM (2006)