MeSH Browser

MeSH Heading: Complement Pathway, Classical
Tree Number(s): G12.274.698
Unique ID: D003171
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003171
Scope Note: Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s): Classical Complement Activation Pathway; Classical Complement Pathway; Complement Activation Pathway, Classical
NLM Classification #: QW 680
Previous Indexing: Complement (1966-1978); Complement Fixation Tests (1966-1978)
Public MeSH Note: 91; was see under COMPLEMENT ACTIVATION 1979-90
History Note: 91(79); was see under COMPLEMENT ACTIVATION 1979-90
Date Established: 1991/01/01
Date of Entry: 1977/12/02
Revision Date: 2016/06/23

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Complement Pathway, Classical MeSH Descriptor Data 2024