MeSH Browser

MeSH Heading: Complement C1
Tree Number(s): D12.776.124.486.274.050
Unique ID: D003172
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003172
Annotation: /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
Scope Note: The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Entry Term(s): C1 Complement; Complement 1; Complement Component 1
Pharm Action: Immunologic Factors
NLM Classification #: QW 680
Previous Indexing: Calcium (1966-1974); Complement (1968-1974)
Public MeSH Note: 2006; see COMPLEMENT 1 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004924
Scope Note: The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Terms: Complement C1 Preferred Term
Term UI T622138
Date12/06/2004
LexicalTag NON
ThesaurusID NLM (2006); Complement Component 1
Term UI T622139
Date12/06/2004
LexicalTag NON
ThesaurusID NLM (2006); C1 Complement
Term UI T631370
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 1
Term UI T009253
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975)

Complement C1 MeSH Descriptor Data 2024