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Complement C3 MeSH Descriptor Data 2024

MeSH Heading
Complement C3
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Entry Term(s)
C3 Complement
C3 Precursor
Complement 3
Complement C3 Precursor
Complement Component 3
Precursor-Complement 3
Pro-Complement 3
Pharm Action
Immunologic Factors
NLM Classification #
QW 680
Previous Indexing
Anaphylaxis (1966-1974)
Chemotaxis (1966-1974)
Complement (1968-1974)
Immune Adherence Reaction (1971-1974)
Neutrophils (1966-1974)
Phagocytosis (1966-1974)
Public MeSH Note
2006; see COMPLEMENT 3 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C3 PRECURSOR was indexed under COMPLEMENT 3 1982-2005
History Note
2006 (1975)
Date Established
Date of Entry
Revision Date
Complement C3 Preferred
Complement C3 Precursor Broader
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