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Trypsin Inhibitor, Kazal Pancreatic MeSH Descriptor Data 2022


MeSH Heading
Trypsin Inhibitor, Kazal Pancreatic
Tree Number(s)
D12.644.822.750.500
D12.776.124.050.850
D12.776.645.688.500
Unique ID
D014359
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D014359
Scope Note
A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.
Entry Version
TRYPSIN INHIB KAZAL
Entry Term(s)
Acidic Pancreatic Trypsin Inhibitor
Inhibitor, Tumor-Associated Trypsin
Kazal Pancreatic Trypsin Inhibitor
Pancreatic Secretory Trypsin Inhibitor
Pancreatic Secretory Trypsin Inhibitor, Kazal
Pancreatic Trypsin Secretory Inhibitor, Kazal
SPINK1
Serine Peptidase Inhibitor, Kazal-Type 1
Serine Protease Inhibitor Kazal-Type 1
Trypsin Inhibitor Kazal Pancreatic
Trypsin Inhibitor, Pancreatic Secretory
Trypsin Inhibitor, Tumor-Associated
Tumor-Associated Trypsin Inhibitor
Registry Number
50936-63-5
Previous Indexing
Pancreatic Juice (1972-1974)
Trypsin Inhibitors (1972-1974)
See Also
Kazal Motifs
Public MeSH Note
91; was see under TRYPSIN INHIBITORS 1975-90
History Note
91(75); was see under TRYPSIN INHIBITORS 1975-90
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2019/04/29
Trypsin Inhibitor, Kazal Pancreatic Preferred
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