Properdin MeSH Descriptor Data 2025

MeSH Heading: Properdin
Tree Number(s): D12.776.124.486.274.965; D12.776.124.790.223.624; D12.776.377.715.182.624
Unique ID: D011414
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011414
Scope Note: A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
Entry Term(s): Complement Factor P
Pharm Action: Immunologic Factors
Registry Numbers: 11016-39-0
CAS Type 1 Name: Complement factor P
NLM Classification #: QW 680
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Complement System Proteins [D12.776.124.486.274]
        
        Anaphylatoxins [D12.776.124.486.274.024]
        
        Complement Activating Enzymes [D12.776.124.486.274.045]
        
        Complement C1 [D12.776.124.486.274.050]
        
        Complement C2 [D12.776.124.486.274.150]
        
        Complement C3 [D12.776.124.486.274.250]
        
        Complement C4 [D12.776.124.486.274.350]
        
        Complement C5 [D12.776.124.486.274.450]
        
        Complement C6 [D12.776.124.486.274.550]
        
        Complement C7 [D12.776.124.486.274.650]
        
        Complement C8 [D12.776.124.486.274.750]
        
        Complement C9 [D12.776.124.486.274.850]
        
        Complement Factor B [D12.776.124.486.274.900]
        
        Complement Inactivator Proteins [D12.776.124.486.274.920]
        
        Complement Membrane Attack Complex [D12.776.124.486.274.930]
        
        Properdin [D12.776.124.486.274.965]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Beta-Globulins [D12.776.124.790.223]
        
        beta 2-Microglobulin [D12.776.124.790.223.100]
        
        beta-Thromboglobulin [D12.776.124.790.223.160]
        
        Complement Factor H [D12.776.124.790.223.200]
        
        Hemopexin [D12.776.124.790.223.338]
        
        Plasminogen [D12.776.124.790.223.580]
        
        Properdin [D12.776.124.790.223.624]
        
        Sex Hormone-Binding Globulin [D12.776.124.790.223.800]
        
        Transferrin [D12.776.124.790.223.839]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Beta-Globulins [D12.776.377.715.182]
        
        beta 2-Microglobulin [D12.776.377.715.182.100]
        
        beta-Thromboglobulin [D12.776.377.715.182.160]
        
        Complement Factor H [D12.776.377.715.182.200]
        
        Hemopexin [D12.776.377.715.182.338]
        
        Plasminogen [D12.776.377.715.182.580]
        
        Properdin [D12.776.377.715.182.624]
        
        Sex Hormone-Binding Globulin [D12.776.377.715.182.800]
        
        Transferrin [D12.776.377.715.182.839]

Properdin Preferred

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