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Complement Factor H MeSH Descriptor Data 2022


MeSH Heading
Complement Factor H
Tree Number(s)
D12.776.124.486.274.920.325.200
D12.776.124.790.223.200
D12.776.377.715.182.200
Unique ID
D017242
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017242
Scope Note
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Entry Term(s)
Factor H
Pharm Action
Complement Inactivating Agents
Registry Number
80295-65-4
Related Numbers
103371-28-4
CAS Type 1 Name
Complement factor H
Previous Indexing
Beta Globulins (1978-1979)
Complement 3b Inactivators (1980-1992)
Glycoproteins (1978-1979)
Public MeSH Note
93; COMPLEMENT FACTOR H was indexed under COMPLEMENT 3B INACTIVATORS 1980-92 & under BETA GLOBULINS and GLYCOPROTEINS 1978-79
Online Note
use COMPLEMENT FACTOR H (NM) to search COMPLEMENT FACTOR H 1978-92
History Note
93; was COMPLEMENT FACTOR H (NM) 1978-92
Date Established
1993/01/01
Date of Entry
1992/05/07
Revision Date
2005/07/07
Complement Factor H Preferred
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