MeSH Browser

MeSH Heading: Complement C5
Tree Number(s): D12.776.124.486.274.450
Unique ID: D003182
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003182
Scope Note: C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Entry Term(s): C5 Complement; Complement 5; Complement C5, Precursor; Complement Component 5; Precursor C5; Pro-C5; Pro-complement 5
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1968-1974); Histamine Liberation (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 5 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C5, PRECURSOR was indexed under COMPLEMENT 5 1991-2005
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004937
Scope Note: C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Terms: Complement C5 Preferred Term
Term UI T623828
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); C5 Complement
Term UI T631387
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 5
Term UI T009296
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Complement Component 5
Term UI T623829
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006)

Concept UI: M0187443
Terms: Complement C5, Precursor Preferred Term
Term UI T600993
Date08/02/2004
LexicalTag NON
ThesaurusID NLM (2006); Precursor C5
Term UI T217446
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Pro-C5
Term UI T217447
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Pro-complement 5
Term UI T217448
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Complement C5 MeSH Descriptor Data 2024