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Complement C5a MeSH Descriptor Data 2022


MeSH Heading
Complement C5a
Tree Number(s)
D12.776.124.486.274.024.270
D12.776.124.486.274.450.250
Unique ID
D015936
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015936
Scope Note
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Entry Term(s)
C5a Complement
Complement 5a
Complement Component 5a
Pharm Action
Immunologic Factors
Registry Number
80295-54-1
CAS Type 1 Name
Complement C5a
Previous Indexing
Anaphylatoxins (1977-1989)
Complement (1972-1975)
Complement 5 (1975-1989)
Public MeSH Note
2006; see COMPLEMENT 5A 1990-2005
History Note
2006 (1990)
Date Established
1990/01/01
Date of Entry
1989/07/14
Revision Date
2016/06/28
Complement C5a Preferred
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