MeSH Browser

MeSH Heading: Complement C5a
Tree Number(s): D12.776.124.486.274.024.270; D12.776.124.486.274.450.250
Unique ID: D015936
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015936
Scope Note: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Entry Term(s): C5a Complement; Complement 5a; Complement Component 5a
Pharm Action: Immunologic Factors
CAS Type 1 Name: Complement C5a
Previous Indexing: Anaphylatoxins (1977-1989); Complement (1972-1975); Complement 5 (1975-1989)
Public MeSH Note: 2006; see COMPLEMENT 5A 1990-2005
History Note: 2006 (1990)
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024381
Scope Note: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Terms: Complement C5a Preferred Term
Term UI T623936
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); Complement 5a
Term UI T047286
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Complement Component 5a
Term UI T623937
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); C5a Complement
Term UI T631388
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006)

Complement C5a MeSH Descriptor Data 2024