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Complement Pathway, Mannose-Binding Lectin MeSH Descriptor Data 2022


MeSH Heading
Complement Pathway, Mannose-Binding Lectin
Tree Number(s)
G12.274.849
Unique ID
D037582
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D037582
Scope Note
Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s)
Lectin-Complement Pathway
Mannan-Binding Lectin Complement Pathway
Mannan-Binding Lectin Pathway (Complement Activation)
Mannose-Binding Lectin Complement Pathway
Previous Indexing
Complement Activation (1989-2002)
See Also
Mannose-Binding Lectin
Public MeSH Note
2003
History Note
2003
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2016/06/23
Complement Pathway, Mannose-Binding Lectin Preferred
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