MeSH Browser

MeSH Heading: Complement Pathway, Mannose-Binding Lectin
Tree Number(s): G12.274.849
Unique ID: D037582
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D037582
Scope Note: Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s): Lectin-Complement Pathway; Mannan-Binding Lectin Complement Pathway; Mannan-Binding Lectin Pathway (Complement Activation); Mannose-Binding Lectin Complement Pathway
Previous Indexing: Complement Activation (1989-2002)
See Also: Mannose-Binding Lectin
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/06/23

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Complement Pathway, Mannose-Binding Lectin MeSH Descriptor Data 2024