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Zalcitabine MeSH Descriptor Data 2022


MeSH Heading
Zalcitabine
Tree Number(s)
D03.383.742.680.245.500.950
D13.570.230.329.950
D13.570.230.500.925
D13.570.685.245.500.950
Unique ID
D016047
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016047
Scope Note
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Entry Term(s)
2',3'-Dideoxycytidine
Dideoxycytidine
HIVID Roche
Hivid
NSC-606170
ddC (Antiviral)
Pharm Action
Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number
6L3XT8CB3I
Related Numbers
7481-89-2
CAS Type 1 Name
Cytidine, 2',3'-dideoxy-
Previous Indexing
Deoxycytidine/analogs & derivatives (1986-1989)
Dideoxynucleosides (1989)
Public MeSH Note
94; was DIDEOXYCYTIDINE 1990-93
Online Note
use ZALCITABINE to search DIDEOXYCYTIDINE 1990-93
History Note
94; was DIDEOXYCYTIDINE 1990-93
Date Established
1990/01/01
Date of Entry
1989/07/14
Revision Date
2017/05/24
Zalcitabine Preferred
NSC-606170 Narrower
Hivid Narrower
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