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Dideoxyadenosine MeSH Descriptor Data 2022


MeSH Heading
Dideoxyadenosine
Tree Number(s)
D03.633.100.759.590.138.325.105
D13.570.230.229.105
D13.570.230.500.105
D13.570.583.138.325.105
Unique ID
D016048
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016048
Annotation
an antiviral; inhibits HIV replication
Scope Note
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Entry Term(s)
2',3'-Dideoxyadenosine
ddA (Antiviral)
Pharm Action
Antimetabolites
Antiviral Agents
Registry Number
4Q86AH641A
Related Numbers
4097-22-7
CAS Type 1 Name
Adenosine, 2',3'-dideoxy-
Previous Indexing
Deoxyadenosine/analogs & derivatives (1975-1989)
Dideoxynucleosides (1989)
Public MeSH Note
90
History Note
90
Date Established
1990/01/01
Date of Entry
1989/07/14
Revision Date
2016/05/31
Dideoxyadenosine Preferred
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