MeSH Browser

MeSH Heading: Didanosine
Tree Number(s): D03.633.100.759.590.616.130; D13.570.230.500.090; D13.570.583.616.130; D13.570.800.573.130
Unique ID: D016049
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016049
Scope Note: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Entry Term(s): 2',3'-Dideoxyinosine; Dideoxyinosine; NSC-612049; Videx; ddI (Antiviral)
Pharm Action: Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number: K3GDH6OH08
Related Numbers: 69655-05-6
CAS Type 1 Name: Inosine, 2',3'-dideoxy-
Previous Indexing: Dideoxynucleosides (1989); Inosine/analogs & derivatives (1987-1989)
Public MeSH Note: 92; was DIDEOXYINOSINE 1990-91
Online Note: use DIDANOSINE to search DIDEOXYINOSINE 1990-91
History Note: 92; was DIDEOXYINOSINE 1990-91
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0024535
Registry Number: K3GDH6OH08
Related Numbers: 69655-05-6
Scope Note: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Terms: Didanosine Preferred Term
Term UI T047687
Date01/01/1999
LexicalTag NON
ThesaurusID; Dideoxyinosine
Term UI T047685
Date01/31/1991
LexicalTag NON
ThesaurusID; 2',3'-Dideoxyinosine
Term UI T047683
Date07/03/1989
LexicalTag NON
ThesaurusID; ddI (Antiviral)
Term UI T047684
Date06/20/1989
LexicalTag NON
ThesaurusID NLM (1990)

Didanosine MeSH Descriptor Data 2024