- Concept UI
- M0024757
- Registry Numbers
- 0
- Scope Note
- A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
- Terms
-
Transforming Growth Factor beta
Preferred Term
Term UI
T048240
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1991)
-
Platelet Transforming Growth Factor
Term UI
T048239
Date02/27/1990
LexicalTag
NON
ThesaurusID
NLM (1991)
-
Bone-Derived Transforming Growth Factor
Term UI
T048241
Date02/27/1990
LexicalTag
NON
ThesaurusID
NLM (1991)
-
TGF-beta
Term UI
T048242
Date02/27/1990
LexicalTag
ABB
ThesaurusID
NLM (1991)
-
TGFbeta
Term UI
T048243
Date02/27/1990
LexicalTag
ABB
ThesaurusID
NLM (1991)
-
Milk Growth Factor
Term UI
T217778
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2001)