MeSH Browser

MeSH Heading: Neurofibromatosis 2
Tree Number(s): C04.557.465.625.650.595.610.500; C04.557.580.600.580.590.655; C04.557.580.600.610.595.610.500; C04.700.631.655; C09.218.807.800.675.500; C09.647.675.500; C10.292.225.750.500; C10.292.910.600.500; C10.562.600.750; C10.574.500.549.700; C16.320.400.560.700; C16.320.700.633.655
Unique ID: D016518
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016518
Annotation: do not confuse with NEUROFIBROMATOSIS 1; coord IM with precoord/neopl term (IM) if relevant
Scope Note: An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
Entry Term(s): Acoustic Neurinoma, Bilateral; Acoustic Schwannomas, Bilateral; Bilateral Acoustic Neurofibromatosis; Central Neurofibromatosis; Familial Acoustic Neuromas; NF2 (Neurofibromatosis 2); Neurofibromatosis II; Neurofibromatosis Type 2; Neurofibromatosis Type II; Neurofibromatosis, Acoustic, Bilateral; Neurofibromatosis, Central NF2; Neurofibromatosis, Central, NF 2; Neurofibromatosis, Central, NF2; Neurofibromatosis, Type 2; Neurofibromatosis, Type II; Neurofibromatosis, central type; Neuroma, Acoustic, Bilateral; Schwannoma, Acoustic, Bilateral
Previous Indexing: Neurilemmoma (1966-1976); Neurofibromatosis 1 (1966-1991); Neuroma, Acoustic (1978-1991)
See Also: Genes, Neurofibromatosis 2; Neurofibromin 2
Public MeSH Note: 1992; NEUROFIBROMATOSIS, CENTRAL, NF2 see NEUROFIBROMATOSIS, CENTRAL, NF-2 see NEUROMA, ACOUSTIC 1989-1991; NEUROMA, ACOUSTIC, BILATERAL see NEUROMA, ACOUSTIC 1989-1991
History Note: 1992; NEUROFIBROMATOSIS, CENTRAL, NF2 use NEUROFIBROMATOSIS, CENTRAL, NF-2 use NEUROMA, ACOUSTIC 1989-1991; NEUROMA, ACOUSTIC, BILATERAL use NEUROMA, ACOUSTIC 1989-91
Date Established: 1992/01/01
Date of Entry: 1991/06/21
Revision Date: 2018/06/29

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Germ Cell and Embryonal [C04.557.465]
    - Neuroectodermal Tumors [C04.557.465.625]
      - Neuroendocrine Tumors [C04.557.465.625.650]
        
        Neurilemmoma [C04.557.465.625.650.595]
        
        Neuroma, Acoustic [C04.557.465.625.650.595.610]
        
        Neurofibromatosis 2 [C04.557.465.625.650.595.610.500]

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Nerve Tissue [C04.557.580]
    - Nerve Sheath Neoplasms [C04.557.580.600]
      - Neurofibroma [C04.557.580.600.580]
        
        Neurofibromatoses [C04.557.580.600.580.590]
        
        Neurofibromatosis 1 [C04.557.580.600.580.590.650]
        
        Neurofibromatosis 2 [C04.557.580.600.580.590.655]

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Nerve Tissue [C04.557.580]
    - Nerve Sheath Neoplasms [C04.557.580.600]
      - Neuroma [C04.557.580.600.610]
        
        Neurilemmoma [C04.557.580.600.610.595]
        
        Neuroma, Acoustic [C04.557.580.600.610.595.610]
        
        Neurofibromatosis 2 [C04.557.580.600.610.595.610.500]

Neoplasms [C04]
- Neoplastic Syndromes, Hereditary [C04.700]
  - Neurofibromatoses [C04.700.631]
    - Neurofibromatosis 1 [C04.700.631.650]
    - Neurofibromatosis 2 [C04.700.631.655]

Otorhinolaryngologic Diseases [C09]
- Ear Diseases [C09.218]
  - Retrocochlear Diseases [C09.218.807]
    - Vestibulocochlear Nerve Diseases [C09.218.807.800]
      - Neuroma, Acoustic [C09.218.807.800.675]
        
        Neurofibromatosis 2 [C09.218.807.800.675.500]

Otorhinolaryngologic Diseases [C09]
- Otorhinolaryngologic Neoplasms [C09.647]
  - Neuroma, Acoustic [C09.647.675]
    - Neurofibromatosis 2 [C09.647.675.500]

Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
  - Cranial Nerve Neoplasms [C10.292.225]
    - Neuroma, Acoustic [C10.292.225.750]
      - Neurofibromatosis 2 [C10.292.225.750.500]

Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
  - Vestibulocochlear Nerve Diseases [C10.292.910]
    - Neuroma, Acoustic [C10.292.910.600]
      - Neurofibromatosis 2 [C10.292.910.600.500]

Nervous System Diseases [C10]
- Neurocutaneous Syndromes [C10.562]
  - Neurofibromatoses [C10.562.600]
    - Neurofibromatosis 1 [C10.562.600.500]
    - Neurofibromatosis 2 [C10.562.600.750]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Neurofibromatoses [C10.574.500.549]
      - Neurofibromatosis 1 [C10.574.500.549.400]
      - Neurofibromatosis 2 [C10.574.500.549.700]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Neurofibromatoses [C16.320.400.560]
      - Neurofibromatosis 1 [C16.320.400.560.400]
      - Neurofibromatosis 2 [C16.320.400.560.700]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Neoplastic Syndromes, Hereditary [C16.320.700]
    - Neurofibromatoses [C16.320.700.633]
      - Neurofibromatosis 1 [C16.320.700.633.650]
      - Neurofibromatosis 2 [C16.320.700.633.655]

Neurofibromatosis 2 Preferred

Concept UI: M0025211
Scope Note: An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
Terms: Neurofibromatosis 2 Preferred Term
Term UI T049405
Date01/01/1999
LexicalTag NON
ThesaurusID; Neurofibromatosis, Central, NF2
Term UI T049407
Date09/05/1990
LexicalTag NON
ThesaurusID NLM (1992); Neurofibromatosis, Central, NF 2
Term UI T049408
Date09/05/1990
LexicalTag NON
ThesaurusID NLM (1992); Bilateral Acoustic Neurofibromatosis
Term UI T369984
Date11/08/1999
LexicalTag NON
ThesaurusID; Neurofibromatosis II
Term UI T369986
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Neurofibromatosis, central type
Term UI T844309
Date05/16/2013
LexicalTag NON
ThesaurusID; Neurofibromatosis Type 2
Term UI T369988
Date11/08/1999
LexicalTag NON
ThesaurusID; Neurofibromatosis, Type II
Term UI T369989
Date11/08/1999
LexicalTag NON
ThesaurusID; Neurofibromatosis, Type 2
Term UI T369990
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); NF2 (Neurofibromatosis 2)
Term UI T369991
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Neurofibromatosis, Central NF2
Term UI T372689
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Central Neurofibromatosis
Term UI T844308
Date05/16/2013
LexicalTag NON
ThesaurusID GHR (2014); Neurofibromatosis, Acoustic, Bilateral
Term UI T049406
Date09/05/1990
LexicalTag NON
ThesaurusID NLM (1992); Neurofibromatosis Type II
Term UI T369987
Date11/08/1999
LexicalTag NON
ThesaurusID

Neuroma, Acoustic, Bilateral Narrower

Schwannoma, Acoustic, Bilateral Narrower

Familial Acoustic Neuromas Related

Neurofibromatosis 2 MeSH Descriptor Data 2024