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Tacrolimus MeSH Descriptor Data 2022


MeSH Heading
Tacrolimus
Tree Number(s)
D02.540.505.810
Unique ID
D016559
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016559
Scope Note
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Entry Term(s)
Anhydrous Tacrolimus
FK-506
FK506
FR-900506
Prograf
Prograft
Tacrolimus Anhydrous
Pharm Action
Immunosuppressive Agents
Calcineurin Inhibitors
Registry Number
WM0HAQ4WNM
Related Numbers
109581-93-3
Y5L2157C4J
CAS Type 1 Name
15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-
Previous Indexing
Antibiotics, Macrolide (1987-1991)
Immunosuppressive Agents (1987-1991)
Public MeSH Note
96; was FK-506 1992-95; FK-506 was indexed under ANTIBIOTICS, MACROLIDE 1989-91 & PYRIDINES 1987-89
Online Note
use TACROLIMUS (NM) to search FK-506 1987-91
History Note
96; was FK-506 1992-95, was FK 506 (NM) 1987-91
Date Established
1992/01/01
Date of Entry
1991/04/24
Revision Date
2016/07/01
Tacrolimus Preferred
Prograf Narrower
FR-900506 Narrower
Anhydrous Tacrolimus Narrower
FK-506 Narrower
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