NLM Logo

Trimetrexate MeSH Descriptor Data 2022


MeSH Heading
Trimetrexate
Tree Number(s)
D03.633.100.786.925
Unique ID
D016597
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016597
Scope Note
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Entry Term(s)
CI-898
JB-11
NSC-249008
NSC-328564
Trimetrexate Hydrate
Trimetrexate Monohydrate, Monoacetate
Pharm Action
Antifungal Agents
Antimetabolites, Antineoplastic
Folic Acid Antagonists
Registry Number
UPN4ITI8T4
Related Numbers
117381-09-6
117381-10-9
52128-35-5
CAS Type 1 Name
2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-
Previous Indexing
Antineoplastic Agents (1966-1991)
Folic Acid Antagonists (1966-1991)
Quinazolines (1966-1991)
Public MeSH Note
92; TRIMETREXATE was indexed under QUINAZOLINES 1979-91
Online Note
use TRIMETREXATE (NM) to search TRIMETREXATE 1980-91
History Note
92; was TRIMETREXATE (NM) 1979-91
Date Established
1992/01/01
Date of Entry
1991/01/25
Revision Date
2017/05/24
Trimetrexate Preferred
JB-11 Narrower
Trimetrexate Monohydrate, Monoacetate Narrower
NSC-328564 Narrower
Trimetrexate Hydrate Narrower
CI-898 Narrower
NSC-249008 Narrower
page delivered in 0.14s