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Aflatoxin M1 MeSH Descriptor Data 2022


MeSH Heading
Aflatoxin M1
Tree Number(s)
D03.383.663.283.119.100
D03.633.100.150.119.100
D23.946.587.142.100
Unique ID
D016607
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016607
Annotation
/antag permitted but consider also ANTITOXINS
Scope Note
A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Entry Version
AFM1
Entry Term(s)
4-Hydroxyaflatoxin B1
Aflatoxin M
Aflatoxin M(1)
Aflatoxin M1, cis(+-)-Isomer
Pharm Action
Poisons
Registry Number
6795-23-9
Related Numbers
25325-49-9
CAS Type 1 Name
Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
Previous Indexing
Aflatoxins (1969-1991)
Public MeSH Note
92; AFLATOXIN M1 was indexed under AFLATOXINS 1980-91
Online Note
use AFLATOXIN M1 (NM) to search AFLATOXIN M1 1979-91
History Note
92; was AFLATOXIN (NM) 1980-91
Date Established
1992/01/01
Date of Entry
1991/01/25
Revision Date
2020/05/27
Aflatoxin M1 Preferred
Aflatoxin M1, cis(+-)-Isomer Narrower
Aflatoxin M Broader
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