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Ophthalmoplegia, Chronic Progressive External MeSH Descriptor Data 2022


MeSH Heading
Ophthalmoplegia, Chronic Progressive External
Tree Number(s)
C05.651.460.700
C10.292.562.750.250
C10.597.622.447.511
C10.668.491.500.700
C11.590.472.250
C18.452.660.560.700
C23.550.291.500.688
C23.888.592.636.447.511
Unique ID
D017246
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017246
Annotation
chronic progressive external ophthalmoplegia with cardiomyopathy & retinitis pigmentosa = KEARNS-SAYRE SYNDROME
Scope Note
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Entry Term(s)
CPEO
Chronic Progressive External Ophthalmoplegia
Graefe Disease
Graefe's Disease
Mitochondrial Ocular Myopathy
Ocular Muscular Dystrophy
Ocular Myopathy of Von Graefe-Fuchs
Ophthalmoplegia, Progressive External
Progressive External Ophthalmoplegia
Previous Indexing
DNA, Mitochondrial (1988-1992)
Mitochondria, Muscle (1972-1992)
Ophthalmoplegia (1966-1992)
Public MeSH Note
93
History Note
93
Date Established
1993/01/01
Date of Entry
1992/05/22
Revision Date
2021/03/12
Ophthalmoplegia, Chronic Progressive External Preferred
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